Bizarre Twist on Amyloid Structure
Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
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Produced by the dreaded MRSA bacterium, PSMα3 is the first known example of a natural peptide that forms amyloid fibers made not of β-sheets, but of neatly stacked α-helices.
ALS patients eliminate more p75 neurotrophin receptor than do healthy controls. P75 urine levels rise as disease worsens.
NIH funds a five-year project to validate biomarkers for clinical trials.
Quality control issues may have scuppered clinical trials.
Mnemonic training reshapes functional connectivity patterns in the brain to facilitate recall akin to that found in memory athletes.
The proposed budget would strike a blow to biomedical research, and science in general.
Route to toxicity converges with RNA binding proteins in membrane-less organelles.
A report claims that in the U.K. dementia research grew substantially since 2008, but more gains are needed to find treatments.
Antibodies against tau lower APP expression and degrade Aβ plaques in transgenic mice.
Although shorter tau peptides formed fibrils in a dish, the R3 domain of tau seeded aggregation in cells.
By virtue of its heavy hydrogen, deutetrabenazine resists metabolism by liver enzymes, allowing clinicians to better titrate the drug.
Prospective study links cardiovascular risk factors to brain amyloid.
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
In tauopathy mice, ApoE4 hastened neuroinflammation and neurodegeneration. No amyloid involved. (Tip: Think A1 astrocytes.)
Next-Generation Tau PET Tracers Strut Their Stuff Are CSF Assays Finally Ready for Prime Time? ApoE and Tau: Unholy Alliance Spawns Neurodegeneration New Evidence Confirms TREM2 Binds Aβ, Drives Protective Response Location, Conformation, Decoration: Tau